Research Publications

​

1. Sahu S, Sullivan T, Mitrophanov A,…Biswas K, Sharan S K,(2023) “Saturation genome editing of 11

codons and exon 13 of BRCA2 variants coupled with chemotherapeutic drug response accurately determines pathogenicity of variants” Plos Genetics. 19(9):e1010940

​

4. Sahu S, Sullivan T, Southon E, Caylor D, Geh J, Sharan S K, (2023) “Saturation and multiplexing of genetic variants using Saturation genome editing” STAR Protocols; 4(4):102702.

​

5. Biswas K, Mitrophanov A, Sahu S…Sharan S K (2023), “Sequencing-based functional assays for

classification of BRCA2 variants in mouse ES cells” Cell Reports Methods (100628)

​

6. Mishra AP, Hartford S, Chittela R, Sahu S,…Sharan S K, “Characterization of BRCA2 R3052Q variant

in mice supports its functional impact as a low risk variant” Cell Death and Disease 14(753)

​

7. Sahu S*, Polawska M, Lim S H, Dutta D* (2023) “CRISPR-based precision medicine for hematologic

disorders: Advancements, Challenges and Prospects” Life Sciences, 333(122165) (*Co-corresponding

author)

​

8. Sahu, S., Albaugh, M.E., Martin, B.K., Patel, N.L., Riffle, L., Mackem, S., Kalen, J.D., and Sharan, S.K.

(2022). Growth factor dependency in mammary organoids regulates ductal morphogenesis during

organ regeneration. Scientific Reports. 12, 7200.

Featured as Editor's choice collection” Organoids” and “Top100 in Cell and Molecular Biology” in 2022.

 

9. Mishra, A.P., Hartford, S.A., Sahu, S., Klarmann, K., Chittela, R.K., Biswas, K., Jeon, A.B., Martin, B.K.,

Burkett, S., Southon, E., et al. (2022). BRCA2-DSS1 interaction is dispensable for RAD51 recruitment

at replication-induced and meiotic DNA double strand breaks. Nature Communications 13,751.

 

10. Sahu, S., Sridhar, D., Abnave, P., Kosaka, N., Dattani, A., Thompson, J.M., Hill, M.A., and Aboobaker,

A. (2021). Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach

wound sites. Elife 10, 1–20.

Featured as Editor's choice in "Science"- May 2021,372 (6543) 699" and "Nature-Lab Animal"- June 2021,(50)147-152".

 

11. Mishra, A.P., Sahu, S., and Sharan, S.K. (2021). Coiled-Coil Domain: Uncoiling Tumor Suppression by

BRCA1. Cancer Research. 81, 6080–6082. (Commentary)

 

12. Sahu, S.*, and Sharan, S.K*. (2020). Translating Embryogenesis to Generate Organoids: Novel

Approaches to Personalized Medicine. iScience 23, 101485. (*Co-corresponding author) [Review]

 

13. Iglesias, M., Felix, D.A., Gutiérrez-Gutiérrez, Ó., De Miguel-Bonet, M.D.M, Sahu, S, Fernández-Varas,

B., Perona, R., Aboobaker, A.A., Flores, I., and González-Estévez, C. (2019). Downregulation of mTOR

Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians.

Stem Cell Reports 13, 405–418.

 

14. Lai, A.G., Kosaka, N., Abnave, P., Sahu, S., and Aboobaker, A.A. (2018). The abrogation of condensin

function provides independent evidence for defining the self-renewing population of pluripotent stem

cells. Developmental Biology, 433, 218–226.

 

15. Dattani, A., Kao, D., Mihaylova, Y., Abnave, P., Hughes, S., Lai, A., Sahu, S., and Aboobaker, A.

(2018). Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone

modifications in animal stem cells. Genome Research 122135.

 

16. Sahu, S., Dattani, A., and Aboobaker, A.A. (2017). Secrets from immortal worms: What can we learn

about biological ageing from the planarian model system? Semin. Cell Dev. Biol. 70, 108–121.

 

17. Lai, A.G., Pouchkina-Stantcheva, N., Di Donfrancesco, A., Kildisiute, G., Sahu, S., and Aboobaker,

A.A. (2017). The protein subunit of telomerase displays patterns of dynamic evolution and conservation

across different metazoan taxa. BMC Evolutionary Biology 17(1):107